What Is in Sciatica PRO+? The Ingredients

A short fatty acid your cells make in small quantities and use inside the mitochondrion. Swallowed, it also behaves as an antioxidant in watery and fatty tissue alike, which is the property that carried it into nerve research. The oral programme converged on 600 mg a day: ALADIN III ran seven months at that amount, SYDNEY 2 weighed 600 against 1,200 and 1,800 mg and found the larger amounts bought nausea, and NATHAN 1 followed people for four years. At 400 mg this row comes nearest to its own literature, and putting the biggest number behind the best evidence was the right call.

A synthetic, fat-soluble cousin of vitamin B1 that crosses cell membranes more readily than thiamine salts. It raises transketolase activity, diverting sugar intermediates away from the pathways that damage small vessels and nerves when glucose runs high. BENDIP randomised 300 mg and 600 mg a day for six weeks, with the clearer signal in the larger arm, and the BEDIP pilot used 400 mg for three weeks. This label supplies 150 mg, half the smallest amount either study used. A 2026 critical review covers both this compound and alpha lipoic acid.

Carnitine ferries fatty acids into the mitochondrion; the acetylated form crosses into nervous tissue more freely. The nerve work is entirely at gram scale. Two pooled 52-week randomised trials gave 1,500 mg or 3,000 mg a day, and pain scores improved in the 3,000 mg arm alone. A later meta-analysis worked in the same range, and Cochrane judged the evidence uncertain even there. Fifty milligrams is a sixtieth of the higher arm, an amount no study has examined.

An Ayurvedan root, milled and dried. Two gaps separate this row from the studies people picture. The first is the unit: trials use standardised extracts, typically 300 to 600 mg a day, and an extract concentrates withanolides that vary widely between plant part and preparation. The second is the subject: that work measures stress, anxiety and sleep, never nerve function. Two cautions belong on the record even at 25 mg, since 600 mg of root extract moved thyroid hormone levels over eight weeks and a case series documents liver injury.

Dried leaf, milled. The compound anyone means here is sulforaphane, which is not sitting in the plant ready to use: an enzyme releases it from glucoraphanin, and that enzyme is readily destroyed by heat. The nerve evidence is a rat study, and human work has used concentrated sprout extract for metabolic endpoints instead, where the largest recent trial missed its primary endpoint.

The spice itself rather than an extract, and culinary turmeric holds little curcumin: an assay of 28 commercial spice products averaged 3.14 per cent curcuminoids by weight, turning 25 mg of powder into roughly 0.8 mg. Trials use 500 to 2,000 mg of standardised curcumin, usually with piperine, because plain curcumin barely reaches the bloodstream. The single trial in diabetic nerve symptoms reached for a nano-formulated curcumin rather than the spice.

The form skin makes under sunlight, and the form that raises blood levels most reliably by mouth. Twenty micrograms is 800 international units, an ordinary daily intake as MedlinePlus describes it. The nerve link is indirect: pooled observational data find low vitamin D more often in people with nerve damage, which is an association rather than a direction of travel. A 2025 meta-analysis found four supplementation trials in painful neuropathy, 320 participants in all, and declined to recommend routine use.

No row here has a firmer nutritional connection to nerves. B12 maintains myelin, the sheath insulating a nerve fibre, and a true shortfall brings numbness, pins and needles and unsteadiness that the clinical literature and a BMJ review describe as reversible when caught early. Risk concentrates after fifty, in vegans, and in long-term metformin users, whom a 2026 scoping review found are often unmonitored. Two micrograms meets the requirement MedlinePlus sets out.

Two numbers because two units are in play: 230 mcg of folic acid is absorbed more efficiently than food folate and therefore counts as 383 micrograms of dietary folate equivalents. That is an everyday amount, well beneath the 1,000 mcg daily ceiling and in line with MedlinePlus. One interaction matters because the same bottle carries B12: folic acid can normalise the blood count that a B12 shortfall disturbs, leaving the nerve damage underneath to go unnoticed.

A coenzyme in more than a hundred reactions, several of them in building neurotransmitters, and a vitamin with an unusual risk curve. Too little causes neuropathy; so does far too much, as a 1983 case series of pyridoxine abuse established. Between those poles, a 2023 systematic review found no trial of B6 alone in peripheral neuropathy. The 1.7 mg here is the adult requirement; what deserves attention is a cupboard holding three products that each contain some.